SPX now features network integrations for AdMob, MoPub, iAd, Millennial Media and a Custom Network connector to integrate virtually any (SDK-enabled) network you want into your SPX setup.

Learn more about how to set it up here:

Configuring SDK Mediation in SPX:Publisher-Owned Ad Network Accounts#OwnedAdNetworkAccounts-Client-basedIntegrations
Configuring SDK Mediation in your App:

iOS: iOS#8.ClientSideMediation

Android: Android#9.ClientSideMediation